Online First

NEPHROPATHOLOGY QUIZ A 54-year-old man with new-onset nephrotic syndrome Bernardo Marques da Costa, Mário Góis, Helena Viana, Fernando Nolasco
A 54-year-old Caucasian airplane technician presented in outpatient evaluation with slow-onset lower extremity oedema, foamy urine and hypercholesterolemia on routine blood tests.
Port J Nephrol Hypert 2018; 32(1): 85-88 Advance Access publication 28 March 2018 DOWNLOAD PDF
REVIEW ARTICLE Diagnosis of monoclonal gammopathy of renal significance Sofia O Correia, Sofia Santos, La Salete Martins, Josefina Santos
Monoclonal gammopathies are a heterogeneous group of disorders characterized by clonal proliferation of immunoglobulin produced by B-lymphocytes or plasma cell clone.
Port J Nephrol Hypert 2018; 32(1): 52-56 Advance Access publication 28 March 2018 DOWNLOAD PDF
REVIEW ARTICLE Off-target effects and adverse outcomes of fibroblast growth factor 23 in chronic kidney disease Giovana S. Di Marco, Marcus Brand
Chronic kidney disease (CKD) patients have a high risk of death, especially cardiovascular death.
Port J Nephrol Hypert 2018; 32(1): 57-63 Advance Access publication 28 March 2018 DOWNLOAD PDF
TUBULAR QUIZ An adult patient with hypokalemia Sandra Brum, Ana Rita Santos, Catarina Silveira, Fernando Nolasco, José Rueff, Joaquim Calado
SP, a southeast Asian male born in East Timor, was 53 years old by the time he came to our attention.
Port J Nephrol Hypert 2018; 32(1): 89-91 Advance Access publication 5 April 2018 DOWNLOAD PDF
PERSPECTIVE Seven years after "Norma 17": what has changed? Ana Farinha, Ana Branco
Although huge medical advances have been made in dialysis treatments, older patients with higher comorbidities or poorer functional status may have limited survival advantage.
Port J Nephrol Hypert 2018; 32(1): 11-15 Advance Access publication 28 March 2018 DOWNLOAD PDF
EDITORIAL Fighting glomerular hegemony: giving the renal tubule the credits it deserves Joaquim Calado
This new editorial feature, the tubular quiz, aims at renewing the interest of Portuguese nephrologists in both clinical evaluation and research in renal physiology and disorders that affect the renal tubule.
Port J Nephrol Hypert 2018; 32(1): 9-10 Advance Access publication 5 April 2018 DOWNLOAD PDF
EDITORIAL A new millennium for women and kidney disease Nicole Pestana, Pedro Vieira, Gil Silva
Taking advantage of this year’s synergy, as World Kidney Day (WKD) and International Women’s Day fall on the same day, the theme chosen for WKD 2018 was “Kidneys and Women’s health”, drawing the attention of the nephrology community to the special features of diseases of the kidney as they affect women.
Port J Nephrol Hypert 2018; 32(1): 5-8 Advance Access publication 5 April 2018 DOWNLOAD PDF
CASE REPORT Light and heavy chain deposition disease - Case report João Cassis, Henrique Silva Sousa, Tiago J Carvalho, Ilídio Rodrigues, Maria Pedro Silveira
Monoclonal immunoglobulin deposition disease is part of the spectrum of monoclonal gammopathy of renal significance.
Port J Nephrol Hypert 2018; 32(2): 180-183 Advance Access publication 25 May 2018 DOWNLOAD PDF
REVIEW ARTICLE Supportive care in advanced chronic kidney disease: Comprehensive conservative care C Belino, C Meng, R Neto, E Gonçalves, M Pestana
Incident and prevalent patients on dialysis are progressively older, with high comorbidity burden and functional dependency.
Port J Nephrol Hypert 2018; 32(2): 149-158 Advance Access publication 25 May 2018 DOWNLOAD PDF
REVIEW ARTICLE The challenge of pregnancy after kidney transplantation Patrícia Cotovio
Kidney transplantation restores the impairment in fertility of end-stage renal disease patients.
Port J Nephrol Hypert 2018; 32(2): 143-148 Advance Access publication 7 June 2018 DOWNLOAD PDF
PERSPECTIVE Peritoneal Dialysis in the elderly: challenge accepted Alice Lança, Maria João Carvalho, Anabela Rodrigues
At present, mostly in Western countries, age is no longer an absolute limitation for renal replacement therapy (RRT); however, some elderly patients are still not considered for peritoneal dialysis (PD), mainly due to late referral, social isolation, low functional capacity or lower life expectancy.
Port J Nephrol Hypert 2018; 32(2): 101-109 Advance Access publication 28 March 2018 DOWNLOAD PDF
CASE REPORT Tubulointerstitial nephritis and uveitis syndrome (TINU) - à propos of 2 cases Ricardo A. Macau, Sara Barreto, Joana Martins, Joana Silva, Filipe Fraga, Rita T Manso, Pedro Bravo, Aura Ramos
The authors present two cases of tubulointerstitial nephritis and uveitis syndrome (TINU).
Port J Nephrol Hypert 2018; 32(2): 184-190 Advance Access publication 18 June 2018 DOWNLOAD PDF
CASE REPORT Acute tubulointersticial nephritis with uveitis: A report of two cases Filipa Silva, Sofia O Correia, Ana Castro, Carla Moreira, Sofia Santos, Jorge Malheiro, Josefina Santos, La Salete Martins, António Cabrita
Tubulointersticial nephritis and uveitis syndrome is an idiopathic and rare cause of acute kidney injury that should not overlooked, because it usually requires specific therapeutic interventions.
Port J Nephrol Hypert 2018; 32(2): 191-195 Advance Access publication 22 June 2018 DOWNLOAD PDF
REVIEW ARTICLE Kidney diseases with ocular involvement: a systematic review Rachele Escoli, Ricardo Oliveira, Paulo Santos, Ana Vila Lobos
Chronic kidney disease is an emerging health problem worldwide. The eye shares striking structural, developmental, and genetic pathways with the kidney, suggesting that kidney and ocular disease may be closely linked.
Port J Nephrol Hypert 2018; 32(3): 223-233 Advance Access publication 31 August 2018 DOWNLOAD PDF
REVIEW ARTICLE The role of bone biopsy in the management of patients with CKD - MBD C. Belino, C. Meng, L. Pereira, C. Carvalho, R. Neto, Frazão JM
The gold standard for diagnosis and classification of bone disorders is the transiliac crest bone biopsy.
Port J Nephrol Hypert 2018; 32(2): 159-164 Advance Access publication 22 June 2018 DOWNLOAD PDF
REVIEW ARTICLE Supportive care in advanced chronic kidney disease: Withholding and withdrawing dialysis therapy C Belino, C Meng, R Neto, E Gonçalves, M Pestana
Over the latest few decades, dialysis has been offered to older and more complex patients.
Port J Nephrol Hypert 2018; 32(2): 165-175 Advance Access publication 22 June 2018 DOWNLOAD PDF
EDITORIAL Tubulointerstitial Nephritis and TINU syndrome: A rising cause of acute kidney injury Ana Carina Ferreira
Much is written and studied about the glomerulus.
Port J Nephrol Hypert 2018; 32(2): 99-100 Advance Access publication 28 June 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Infectious risk of elderly patients on peritoneal dialysis: Experience of a portuguese center Carolina L Belino, Patrícia S Barreto, Maria C Santos, Ana M Gomes, Isabel Fonseca, João C Fernandes
Background: The goal of this study was to compare the risk of peritoneal dialysis‑related infections in younger and older patients and to identify risk factors for infection in elderly patients.
Port J Nephrol Hypert 2018; 32(2): 121-126 Advance Access publication 25 June 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Nutritional assessment of patients with chronic kidney disease under treatment with peritoneal dialysis Lívia Almeida Alvarenga, Michelle Andrade Moreira, Beatriz Cristina Pereira, Ana Paula Carlos Cândido, Aline Silva de Aguiar
Introduction: Peritoneal dialysis is a renal replacement therapy that allows the patient to live with a certain degree of autonomy and flexibility.
Port J Nephrol Hypert 2018; 32(2): 127-135 Advance Access publication 25 June 2018 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ An unlikely case although it exists Filipa B Mendes, Bernardo Marques da Costa, Mário Góis, Helena Viana, Ana Paula Silva, Fernando Nolasco
We present a case of 41-year-old man, native of Angola, accountant, who frequently visits Portugal.
Port J Nephrol Hypert 2018; 32(2): 196-200 Advance Access publication 27 June 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Evaluation of the Portuguese kidney transplant allocation system: comparative results from a simulation Bruno A Lima, Helena Alves
The distribution of such a scarce resource as deceased donor kidneys should be made by observing a balance between fairness, efficiency and flexibility.
Port J Nephrol Hypert 2018; 32(2): 136-142 Advance Access publication 28 June 2018 DOWNLOAD PDF
IN-DEPTH CASE DISCUSSION Making the diagnosis of Alport syndrome and the differential diagnosis of a severe superimposed second glomerulopathy in a young boy João Paulo Oliveira
In a previous issue of this journal, Neves et al.1 reported the occurrence of a severe,  normocomplementemic, acute nephritic syndrome at age 4½ years, in a boy with past medical history of self-limited episodes of macroscopic hematuria associated with respiratory infections, who was eventually diagnosed with Alport syndrome (AS) more than 10 years afterwards.
Port J Nephrol Hypert 2018; 32(2): 110-120 Advance Access publication 28 June 2018 DOWNLOAD PDF
TUBULAR QUIZ An adult patient with hypernatremia: a case of water balance equipoise Nuno Fonseca, Ana Messias, Ana Raquel Garrote, David Navarro, Orlando Cardoso, Fernando Maltez, Joaquim Calado, Fernando Nolasco
A 67‑year‑old black man from Cape Verde was admitted to our emergency department with a two‑day history of altered mental status and fever.
Port J Nephrol Hypert 2018; 32(2): 201-203 Advance Access publication 28 June 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Interventional nephrology - five years dealing with central stenosis: immediate and long-term results Helena Pinto, Emanuel Ferreira, Nuno Afonso, Catarina Teixeira, Fátima Costa, Rui Alves
Introduction: Improved technique and materials have allowed us to prolong the life of hemodialysis vascular access using percutaneous transluminal balloon angioplasty (PTA).
Port J Nephrol Hypert 2018; 32(3): 211-215 Advance Access publication 28 August 2018 DOWNLOAD PDF
CASE REPORT Immunoglobulin G4-related disease mimicking multiple myeloma Marta Sofia Costa, Andreia Silva, Luísa Costa, Ana Rodrigues, Tiago Barra, Sérgio Lemos, Jesús Garrido
Immunoglobulin G4‑related disease (IgG4‑RD) is a rare, poorly understood immune mediated disorder.
Port J Nephrol Hypert 2018; 32(3): 217-222 Advance Access publication 10 September 2018 DOWNLOAD PDF
CASE REPORT Light chain deposition disease: atypical associations in a rare disease Ivo Cunha, Sandra Silva, Rui Henrique, Maximino Costa
Light chain deposition disease is a systemic disorder characterized by deposition of monoclonal light chains in various organs.
Port J Nephrol Hypert 2018; 32(3): 235-238 Advance Access publication 21 September 2018 DOWNLOAD PDF
LETTER TO THE EDITOR Acute renal injury as a manifestation of Addison syndrome in a 66-year-old female patient Igor Romaniouk, Maria Araznzazu, Antonio Romero
Addison syndrome is a hormonal deficiency caused by damage to the adrenal gland which leads to hypofunction or primary adrenal insufficiency.
Port J Nephrol Hypert 2018; 32(1): 83-84 Advance Access publication 13 March 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Urine volume and residual renal function decline among patients on peritoneal dialysis ? searching for associations Ricardo A. Macau, Joana R. Silva, Andreia Leite, Rita Magriço, Pedro Bravo, Fernando Teixeira e Costa, Aura Ramos
Introduction: Preservation of urine volume and residual renal function in patients on peritoneal dialysis (PD) is a major concern.
Port J Nephrol Hypert 2018; 32(1): 35-41 Advance Access publication 13 March 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Color doppler ultrasound assessment of juxta-anastomotic stenosis in radiocephalic arteriovenous fistulas Ana Pimentel, Paulo Almeida, Norton de Matos, Luís Loureiro, Gabriela Teixeira, Duarte Rego, Sérgio Teixeira, Joaquim Pinheiro, Isabel Fonseca, Telmo Carvalho, José Queirós
Background: Juxta-anastomotic stenosis (JAS) is a common complication of radiocephalic arteriovenous fistulas.
Port J Nephrol Hypert 2018; 32(1): 29-34 Advance Access publication 13 March 2018 DOWNLOAD PDF
CASE REPORT Coexistence of pheochromocytoma and renal artery stenosis in a pediatric patient with hypertension Inês Serras, Rute Baeta Baptista, Telma Francisco, Anaxore Casimiro, David Lito, Rui Alves, Margarida Abranches
Pheochromocytoma and renal artery stenosis are surgically treatable causes of hypertension.
Port J Nephrol Hypert 2018; 32(1): 78-82 Advance Access publication 13 March 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Tell me your weight before kidney transplant and I?ll tell you your risks Joana Silva Costa, Emanuel Ferreira, Rita Leal, Catarina Romãozinho, Lídia Santos, Fernando Macário, Rui Alves, Arnaldo Figueiredo
Introduction and aims: Overweight is highly prevalent in kidney transplant candidates and it has been associated with multiple post-transplant complications.
Port J Nephrol Hypert 2018; 32(1): 22-28 Advance Access publication 28 February 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Hemodialysis arteriovenous fistula outcomes in elderly patients: a single-centre cohort Hugo Ferreira, Hugo Diniz, Patrícia Martins, Luís Coentrão
The cohort of older age pre‑dialysis patients is growing steadily. However, “Fistula First” may not always be the best strategy due to poorer arteriovenous fistula outcomes in this population.
Port J Nephrol Hypert 2018; 32(1): 16-21 Advance Access publication 14 February 2018 DOWNLOAD PDF
CASE REPORT C3 glomerulopathy: a rare kidney histological presentation of multiple myeloma Joana Silva Costa, Catarina Romãozinho, Luís Rodrigues, Carol Marinho, Vitor Sousa, Jorge Pratas, Maria Augusta Cipriano, Rui Alves
C3 Glomerulopathy is a rare disease caused by abnormal control of the alternative complement pathway, resulting in a predominant glomerular C3 deposition.
Port J Nephrol Hypert 2018; 32(1): 69-74 Advance Access publication 10 February 2018 DOWNLOAD PDF
CASE REPORT Prostate involvement in granulomatosis with polyangiitis: response to rituximab treatment David Navarro, Charles Pusey
Granulomatosis with polyangiitis is an autoimmune vasculitic condition strongly associated with anti-neutrophil cytoplasm antibodies.
Port J Nephrol Hypert 2018; 32(1): 75-77 Advance Access publication 10 February 2018 DOWNLOAD PDF
REVIEW ARTICLE Clinical implications of anti-HLA antibodies testing in kidney transplantation Jorge Malheiro, Sandra Tafulo
Alloantibodies against donor human leukocyte antigens (HLA), termed as donor‑specific antibodies (DSA), are one of the most important factors for both early and late kidney allograft dysfunction.
Port J Nephrol Hypert 2018; 32(1): 42-51 Advance Access publication 1 February 2018 DOWNLOAD PDF
CASE REPORT C3 glomerulonephritis disguised as Postinfectious GN Alice Lança, Paulo Santos, Karina Lopes, Francisco Ferrer, Ana Vila Lobos
It is not uncommon for atypical cases of postinfectious glomerulonephritis (PIGN) to be confused with C3 glomerulonephritis (C3GN) due to considerable overlap of their clinical and histopathological features.
Port J Nephrol Hypert 2018; 32(1): 64-68 Advance Access publication 1 February 2018 DOWNLOAD PDF
MINI REVIEW IgG4-tubulointerstitial nephritis: a literature review following 5 cases in a single centre Joana Rocha, Amy Kang, Nikki Wong, Joseph Westaby, Candice Roufosse, Terence Cook
Immunoglobulin G4‑related disease is a recently described systemic fibro‑inflammatory disease, characterized by an infiltration of abundant IgG4+ plasma cells and lymphocytes, leading to tumour‑like swellings of the involved organs, and variable degrees of fibrosis.
Port J Nephrol Hypert 2017; 31(4): 254-261 Advance Access publication 11 December 2017 DOWNLOAD PDF
LETTER TO THE EDITOR Open data on kidney transplantation Nuno Moreira Fonseca
To the Editor,In his recent article “A call for open data of renal transplantation in Portugal” Lima calls for free, accessible, and disaggregated data on kidney transplantation.While I fully support this request, I must take issue with the stakeholders it addresses.
Port J Nephrol Hypert 2017; 31(4): 321 Advance Access publication 21 December 2017 DOWNLOAD PDF
COMMENT Vascular access unsolved problem - When, which and for whom? Maria Guedes Marques, Pedro Maia
I congratulate the authors on their recent analysis of the dilemma regarding the timing and type of vascular access creation1-3.
Port J Nephrol Hypert 2017; 31(4): 283-285 Advance Access publication 28 December 2017 DOWNLOAD PDF
CASE REPORT Crescentic IgA nephropathy with preserved renal function Ricardo A. Macau, Joana R. Silva, Hélder Coelho, Pedro Bravo, Fernanda Carvalho, Aura Ramos
Crescentic glomerulonephritis is a severe form of glomerular inflammation. IgA nephropathy (IgAN) is the most common primary glomerulonephritis and rarely presents as crescentic glomerulonephritis with rapidly progressive glomerulonephritis.
Port J Nephrol Hypert 2017; 31(4): 315-320 Advance Access publication 2 January 2018 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ Acute allograft dysfunction: a case hanging by a thread Marta Sofia Costa, Sofia Coelho, Ivo Laranjinha, Mário Góis, Helena Viana, Fernando Nolasco
A 49-year-old man with end-stage renal disease secondary to ANCA-MPO vasculitis received a deceased-donor allograft kidney with two mismatches.
Port J Nephrol Hypert 2017; 31(4): 322-325 Advance Access publication 3 January 2018 DOWNLOAD PDF
PERSPECTIVE Is tolvaptan a promising ally in the treatment strategy of autosomal dominant polycystic kidney disease? Sara Fernandes, Catarina Teixeira, Luís Falcão, Ana Cortesão Costa, Edgar A F de Almeida
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic diseases in humans.
Port J Nephrol Hypert 2017; 31(4): 243-248 Advance Access publication 4 January 2018 DOWNLOAD PDF
REVIEW ARTICLE Lecithin-cholesterol acyltransferase deficiency: a review for clinical nephrologists Rute Carmo, I. Castro-Ferreira, João Paulo Oliveira
Lecithin-cholesterol acyltransferase (LCAT) is the enzyme responsible for esterification of free cholesterol on the surface of lipoproteins, particularly in high-density lipoproteins (HDL), and is also involved in the reverse transport of cholesterol from peripheral tissues to the liver.
Port J Nephrol Hypert 2017; 31(4): 286-292 Advance Access publication 3 January 2018 DOWNLOAD PDF
REVIEW ARTICLE The role of bone biomarkers and new imaging techniques in the management of patients with CKD-MBD C Belino, C Meng, L Pereira, C Carvalho, R Neto
Chronic kidney Disease – Mineral and Bone Disorder (CKD-MBD) encompasses abnormalities in bone turnover, volume and mineralization, compromising bone quantity and quality.
Port J Nephrol Hypert 2017; 31(4): 293-299 Advance Access publication 2 January 2018 DOWNLOAD PDF
REVIEW ARTICLE Glucosylceramides and kidney disease Alberto Ortiz, Maria Dolores Sanchez?Niño
Glucosylceramides are part of the wider family of glycosylceramides. Glucosylceramide synthase catalyzes the incorporation of a single glucose residue into ceramide to yield glucosylceramide.
Port J Nephrol Hypert 2017; 31(3): 200-206 Advance Access publication 3 October 2017 DOWNLOAD PDF
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