Online First

CASE REPORT Cortical nephrocalcinosis asymmetrically involving the kidneys: a case report documenting the development via imaging Ana Isabel Simões Ferreira, Natália Ferreira, João Leitão, José Fonseca-Santos
We report the case of a 38-year-old man with known human immunodeficiency virus infection who presented with severe Bordetella Bronchiseptica pneumoniae that led to septic shock and acute renal insufficiency, after which he developed bilateral cortical nephrocalcinosis, affecting most severely the right kidney with associated atrophy.
Port J Nephrol Hypert 2017; 31(4): 249-253 Advance Access publication 17 November 2017 DOWNLOAD PDF
MINI-REVIEW Hyperinfection syndrome with hypereosinophilia and chronic kidney disease: case report and review Noélia Lopez, Alice Fortes, Estela Nogueira, Iolanda Godinho, Sofia Jorge, Tiago Marques, Paulo Fernandes, António G Costa
Chronic kidney disease (CKD) is associated to significant infection incidence and severity, the cause of death of, approximately, 20% of end-stage renal disease patients.
Port J Nephrol Hypert 2017; 31(4): 243-247 Advance Access publication 17 November 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Factors associated with early fistula failure: how to improve it C. Belino, S. Pereira, A. Ventura, V. Martins, C. Nogueira, JC. Fernandes
Introduction: Around the world, risk factors for fistula failure have been considered in vascular access planning in order to improve results. However, primary fistula failure rates seem to be increasing. 
Port J Nephrol Hypert 2017; 31(4): 237-242 Advance Access publication 17 November 2017 DOWNLOAD PDF
PERSPECTIVE Salt and water retention in CKD patients: Too much of a good thing? Pedro Ponce
A 54-year-old patient with chronic kidney disease (CKD), stage 4, was admitted to the nephrology clinic, in the middle of August: he felt tired; his blood pressure was a little lower than usual; he had no oedema, his haemoglobin level had remained stable for a 6-month period but his serum creatinine had increased from 2.3 mg/dl since the last visit, 6 months ago, to 3.1 mg/dl.
Port J Nephrol Hypert 2017; 31(1): 5-6 Advance Access publication 3 February 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Are Cranberry Capsules Effective and Safe in Preventing Urinary Tract Infections in Kidney Transplantation? A randomized pilot clinical trial. Tiago Assis Pereira, Ana Raquel Fernandes, Artur Mendes, Regina Oliveira, Ana Casqueiro, Rita Birne...
Introduction: Kidney transplant (KT) recipients are highly susceptible to urinary tract infections (UTIs).
Port J Nephrol Hypert 2017; 31(1): 18-24 Advance Access publication 21 February 2017 DOWNLOAD PDF
CASE REPORT Membranous nephropathy: A diagnostic and therapeutic challenge? Joana Gameiro, Sofia Jorge, José António Lopes, Lurdes Correia, António Gomes da Costa
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in Caucasian adults aged over 60 years old. Approximately two thirds of cases of membranous nephropathy (MN) in adults are primary (idiopathic), and the remaining are secondary forms which have been attributed to a variety of agents or conditions.
Port J Nephrol Hypert 2017; 31(1): 42-46 Advance Access publication 14 February 2017 DOWNLOAD PDF
CASE REPORT Rare aetiology of obstructive kidney injury: Bilateral ureteral endometriosis Maria Inês Correia, Pedro Vieira, António M Gonçalves, José M Durães, Dina Santos, Nuno G Rosa, Gil Silva
Endometriosis is highly prevalent in women at the reproductive age, ranging from 6-10%, though ureteral involvement is rare, only seen in 0.1% of the cases, but may lead to urinary tract obstruction with potential renal function loss.
Port J Nephrol Hypert 2017; 31(1): 47-49 Advance Access publication 22 February 2017 DOWNLOAD PDF
COMMENT Analysis of trends in prevalence, awareness, treatment and control of high blood pressure in Portugal: Examples of successful interventions against hypertension Massimo Volpe, Giuliano Tocci
Essential hypertension is currently the major driver for cardiovascular (CV) morbidity and mortality worldwide.
Port J Nephrol Hypert 2017; 31(1): 12-14 Advance Access publication 2 March 2017 DOWNLOAD PDF
CASE REPORT Kidney transplantation in a patient with preformed and exclusively anti-HLA-Cw donor specific antibody Sofia Santos, Ana Castro, Andreia Campos, Sofia Pedroso, Leonídio Dias, Castro Henriques
We report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant.
Port J Nephrol Hypert 2017; 31(1): 50-53 Advance Access publication 8 March 2017 DOWNLOAD PDF
COMMENT The holy grail of renal protection in diabetes mellitus: is SGLT2 inhibition fulfilling its promise? Joaquim Calado
The manuscript from Lambers-Heerspink et al that appeared in this year’s January issue of the J Am Soc Nephrol1 reports a secondary analysis of the Canagliflozin Treatment and Trial Analysis versus Sulphonylurea (CANTATA-SU)2, that focus on the renal outcomes.
Port J Nephrol Hypert 2017; 31(1): 15-17 Advance Access publication 27 March 2017 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ Severe granulomatosis with polyangiitis Gisela Lage, Antónia Furtado, Ana Marta Gomes, Cátia Cunha, Daniela Lopes, Ana Ventura, Clara Almeida, João Carlos Fernandes
An 81-year-old female presented at the emergency room with asthenia, anaemia and oliguria. In the previous 6 months, she had experienced recurrent epistaxis, nasal crusting and saddle nose.
Port J Nephrol Hypert 2017; 31(1): 63-66 Advance Access publication 27 March 2017 DOWNLOAD PDF
PERSPECTIVE Local health communities Cipriano Justo
Active citizenship is not based on the idea of practicing good or benevolent philanthropy, but on the principle of mutuality and reciprocity, the glue that binds people together and supports the construction of society.
Port J Nephrol Hypert 2017; 31(1): 7-11 Advance Access publication 22 March 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Renal involvement in rheumatoid arthritis: analysis of 53 renal biopsies Mário Góis, Fernanda Carvalho, Helena Sousa, Ana Carina Ferreira, João Sousa, Fernando Nolasco
Background: Rheumatoid arthritis (RA) is a systemic inflammatory disorder characterized by joint inflammation, associated with autoantibody production.
Port J Nephrol Hypert 2017; 31(1): 25-30 Advance Access publication 10 March 2017 DOWNLOAD PDF
PERSPECTIVE Young nephrologists: The portuguese picture Carina Ferreira
For the past four years I have had the opportunity to work for the Young Nephrologists’ Platform (YNP) Board, and for the past two years I have chaired and represented this body of the European Renal Association – European Renal and Transplant Association (ERAEDTA), which was developed to help nephrologists younger than 40 years of age.
Port J Nephrol Hypert 2017; 31(2): 79-80 Advance Access publication 11 may 2017 DOWNLOAD PDF
REVIEW ARTICLE Are there benefits of a high potassium diet, even in the CKD patient? Biff F. Palmer, Deborah J. Clegg
Recent data have demonstrated dietary intake of potassium (K+) is well below current recommended nutritional guidelines, and K+ deficiency has been implicated in many diseases to include cardiovascular disease, kidney stones, and osteoporosis.
Port J Nephrol Hypert 2017; 31(2): 115-121 Advance Access publication 11 May 2017 DOWNLOAD PDF
PERSPECTIVE Ethics and living donation in renal transplantation Ana Carina Ferreira, Diogo Pais
Living kidney transplantation is the treatment that offers the best benefits in end‑stage kidney disease, and one in which Beauchamp and Childress’ ethical principles should govern proceedings.
Port J Nephrol Hypert 2017; 31(2): 81-85 Advance Access publication 18 May 2017 DOWNLOAD PDF
REVIEW ARTICLE Diabetic Nephropathy and its two phenotypes: the proteinuric and non-proteinuric Regina Silva, Catarina Meng, Luís Coentrão
The typical progression of diabetic nephropathy is from the normoalbuminuric stage to microalbuminuria (urinary albumin creatinine rate, UACR, 30-300 mg/g) to end in overt proteinuria.
Port J Nephrol Hypert 2017; 31(2): 122-131 Advance Access publication 29 May 2017 DOWNLOAD PDF
EDITORIAL Anion gap metabolic acidosis Biff F. Palmer, Deborah J. Clegg
Metabolic acidosis is defined as a low arterial blood pH in conjunction with a reduced serum HCO3- concentration.
Port J Nephrol Hypert 2017; 31(2): 73-78 Advance Access publication 12 June 2017 DOWNLOAD PDF
PERSPECTIVE Acute Kidney Injury and Extracorporeal Life Support João Mendes, Pedro Ponce
The overall acute kidney injury (AKI) incidence of 7 to 10% in hospitalized patients has increased dramatically over the last several decades at a rate of 13%/year, which is probably related to increasing patient age, a higher comorbidity burden (including chronic kidney disease), and the aggressive nature of many diagnostic tests and treatments utilized in this population (1).
Port J Nephrol Hypert 2017; 31(2): 86-90 Advance Access publication 16 June 2017 DOWNLOAD PDF
CASE REPORT Recurrence of anti-factor H associated C3 glomerulonephritis in the kidney allograft Rita Magriço, Fernanda Carvalho, António Pedro Alves de Matos, Cristina Jorge, Ana Mateus, Pedro Cruz, Carlos Oliveira, Manuel Amoedo, Fernando Nolasco, Aura Ramos
C3 glomerulonephritis is a rare disease defined by deposits of C3 on immunofluorescence due to dysregulation of the alternative pathway of the complement cascade.
Port J Nephrol Hypert 2017; 31(2): 132-136 Advance Access publication 21 June 2017 DOWNLOAD PDF
CASE REPORT IgA Nephropathy in a young adult with Nephrotic Syndrome: Case report João Cassis, Henrique Silva Sousa, Rita Theias Manso, Sância Ramos, Domingos Machado
IgA Nephropathy has many clinical presentations, of which Nephrotic Syndrome is possibly the rarest.
Port J Nephrol Hypert 2017; 31(2): 137-139 Advance Access publication 21 June 2017 DOWNLOAD PDF
CASE REPORT Severe Systemic Lupus Erythematosus presentation in patient with alternative complement pathway mutations Fernando Pereira, Liliana Cunha, Pedro Campos, Ana Gaspar, Rita Manso, Karina Soto
Systemic lupus erythematosus (SLE) is an autoimmune disease which can involve almost any organ, making its difficult therapeutic approach.
Port J Nephrol Hypert 2017; 31(2): 140-144 Advance Access publication 21 June 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Renal pathology in HCV infected patients - Report of 148 patients and review of the literature Isabel Mesquita, Helena Sousa, Fernanda Carvalho, Fernando Nolasco
Background: Hepatitis C virus infection (HCV) is a major public health problem with a reported incidence of 3‑4 million cases per year.
Port J Nephrol Hypert 2017; 31(2): 91-99 Advance Access publication 28 June 2017 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ A rare morphologic pattern in a common disease, or two diseases? Mário Góis, Ana Valada Marques, Isabel Mesquita, Helena Sousa, Fernanda Carvalho, Fernando Nolasco
An 86‑year‑old male presented at the emergency room with lower limb oedema, asthenia and a progressive decrease in urine output, with one week of evolution.
Port J Nephrol Hypert 2017; 31(2): 145-148 Advance Access publication 30 June 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Recombinant tissue plasminogen activator plus citrate versus citrate alone as catheter lock for tunnelled catheters of haemodialysis Rita Magriço, José Paulo Santos, Susana Colaço, Sara Dias, Aura Ramos
Introduction: The solution used to fill the lumens of the tunnelled catheters for haemodialysis (lock) influences catheter‑related complications, such as inadequate blood flow and dialysis efficacy.
Port J Nephrol Hypert 2017; 31(2): 100-107 Advance Access publication 30 June 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Urinary tract infections under 24 months old: Is it possible to predict the risk of renal scarring? Ana M. Miranda, Catarina Garcia, Vanda A. Bento, Sara Pinto
Background: Urinary tract infection is one of the most common bacterial infections in the first two years of life and it can lead to irreversible renal scarring.
Port J Nephrol Hypert 2017; 31(2): 108-114 Advance Access publication 30 June 2017 DOWNLOAD PDF
REVIEW ARTICLE Dialysis catheter malfunction Maria G Marques, Pedro Maia, Pedro Ponce
Vascular access is a crucial factor in the treatment of hemodialysis patients. Dialysis catheters are associated with higher mortality than fistulas, meaning they should be the last choice for most patients. Although they have many drawbacks, catheters play an important role in providing a reliable vascular access in some patients.
Port J Nephrol Hypert 2017; 31(3): 184-191 Advance Access publication 6 September 2017 DOWNLOAD PDF
CASE REPORT Amyloidosis related to HIV - An unusual cause of nephrotic syndrome in HIV patients Sofia Coelho, Ana Fernandes, Elsa Soares, Patrícia Valério, Ana Farinha, Ana Natário, Joana Sá
Human immunodeficiency virus infection is a multisystemic disease which causes kidney disease in a variable proportion of infected patients.
Port J Nephrol Hypert 2017; 31(3): 207-211 Advance Access publication 9 September 2017 DOWNLOAD PDF
COMMENT Recurrence of anti factor H associated C3 glomerulonephritis in the kidney allograft Fernando G. Cosio
In the last issue of the Journal Magriço et al. reported the case of a patient with C3 glomerulonephritis (C3GN) and evidence of recurrence in his second kidney allograft. Patient is presently being considered for a third allograft (first allograft lost due to thrombosis).
Port J Nephrol Hypert 2017; 31(2): 183 Advance Access publication 12 July 2017 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ End-Stage Renal Disease in Childhood - A rare biopsy-proven diagnosis Catarina Eusébio, Miguel Oliveira, Mário Góis, Helena Sousa, Joaquim Calado, Raquel Santos, Margarida Abranches, Fernando Nolasco
A 16-year-old male was referred to our paediatrics nephrology department for severe renal dysfunction.
Port J Nephrol Hypert 2017; 31(3): 221-223 Advance Access publication 20 September 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Predialysis vascular access creation: To whom and when Rachele Escoli, Ivan Luz, Paulo Santos, Ana Vila Lobos
Aims: The optimal timing of predialysis vascular access surgery remains uncertain. This study goal was to evaluate the influence of kidney function and clinical characteristics at predialysis vascular access surgery on the likelihood of initiating hemodialysis during follow-up.
Port J Nephrol Hypert 2017; 31(3): 162-166 Advance Access publication 16 September 2017 DOWNLOAD PDF
CASE REPORT Rivaroxaban-related nephropathy Miguel Oliveira, Carla Lima, Mário Góis, Helena Viana, Fernanda Carvalho, Sérgio Lemos
Novel oral anticoagulants (NOAC) are a group of drugs recently approved for the treatment of patients at high risk of arterial or venous thrombosis.
Port J Nephrol Hypert 2017; 31(3): 212-216 Advance Access publication 20 September 2017 DOWNLOAD PDF
REVIEW ARTICLE Symptom control in End Stage Renal Disease Ana Farinha
Chronic kidney disease (CKD) patients experience a high burden of symptoms that are not always recognized or relieved by standard measures.
Port J Nephrol Hypert 2017; 31(3): 192-199 Advance Access publication 18 September 2017 DOWNLOAD PDF
PERSPECTIVE A call for open data of renal transplantation in Portugal Bruno A Lima
Open data refers to data that can be accessed, used, modified and shared by any person and for any purpose, without any restrictions.
Port J Nephrol Hypert 2017; 31(3): 155-157 Advance Access publication 18 September 2017 DOWNLOAD PDF
CASE REPORT Atypical renal presentation of antiphospholipid syndrome Ana Gaspar, Rita Manso, Fernando Pereira, Liliana Cunha, Luís Inchaustegui, Adelaide Serra, Bruno Rodrigues, Pedro Correia
Antiphospholipid syndrome (APS) is a systemic autoimmune disease which can occur as a primary disease or in association with other autoimmune diseases, the most frequent being Systemic Lupus Erythematosus (SLE).
Port J Nephrol Hypert 2017; 31(3): 217-220 Advance Access publication 29 September 2017 DOWNLOAD PDF
PERSPECTIVE Tips for publishing an original article Ana Carina Ferreira, Pedro Escada
Writing an article is a goal for not only many researchers, but also for many clinicians.
Port J Nephrol Hypert 2017; 31(3): 158-161 Advance Access publication 2 October 2017 DOWNLOAD PDF
REVIEW ARTICLE Glucosylceramides and kidney disease Alberto Ortiz, Maria Dolores Sanchez?Niño
Glucosylceramides are part of the wider family of glycosylceramides. Glucosylceramide synthase catalyzes the incorporation of a single glucose residue into ceramide to yield glucosylceramide.
Port J Nephrol Hypert 2017; 31(3): 200-206 Advance Access publication 3 October 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Diagnosis and treatment of haemodialysis vascular access problems without iodinated contrast: A single-centre experience Joana Francisca Rocha, Mónica Fructuoso, Pedro Filipe Sousa, Joana Ferreira, Rui Miguel Abreu, Catarina Eusébio, Teresa Morgado
Introduction: The use of iodinated contrast angiography in the diagnostic and therapeutic approach to arteriovenous access (AVA) problems is limited by nephrotoxicity and allergic reactions.
Port J Nephrol Hypert 2017; 31(3): 175-182 Advance Access publication 3 October 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Echocardiography and cardiovascular risk: The relationship in the renal transplant recipient Miguel Gonçalves, Micaela Neto, Nicole Pestana, Luís Resende, Pedro Vieira, Susana Gomes, José Durães, Nuno Rosa, José Alves Teixeira, Gil Silva
Introduction: Cardiovascular disease (CVD) is the major cause of death among renal transplant recipients (RTR).
Port J Nephrol Hypert 2017; 31(3): 167-174 Advance Access publication 3 October 2017 DOWNLOAD PDF
ORIGINAL ARTICLE Survival of hemodialysis patients: A new reality? Carolina Belino, Augusto Coelho, Susana Pereira, Daniela Lopes, Ana Marta Gomes, Ana Ventura
Introduction: Survival rates of haemodialysis patients have increased worldwide over the last decade. The purposes of this study were to analyze the 10‑year survival rate and to identify mortality risk factors in a Portuguese cohort.
Port J Nephrol Hypert 2017; 31(1): 37-41 Advance Access publication 31 March 2017 DOWNLOAD PDF
REVIEW ARTICLE C3 glomerulopathies: A new category encompassing rare complement mediated glomerulonephritis Fernanda Carvalho, Fernando Nolasco
Disease associated membranoproliferative glomerulonephritis (MPGN) has been well‑known for decades. Recently, advances in the understanding of the complement system have shown its direct influence on MPGN‑related conditions and conditions related to other morphologic entities.
Port J Nephrol Hypert 2016; 30(4): 239-245 Advance Access publication 22 December 2016 DOWNLOAD PDF
PERSPECTIVE In clinical practice, more information is not always good: The problem of overdiagnosis António Vaz Carneiro
The definition of disease is not as straightforward as it may seem. The combination of signs and symptoms, together with interpretation of the results of confirmatory ancillary tests, allows us to have a probabilistic estimate of disease but we can never be absolutely sure that a non‑ambiguous clinical entity is in play.
Port J Nephrol Hypert 2016; 30(3): 170-172 Advance Access publication 13 September 2016 DOWNLOAD PDF
PERSPECTIVE Dialysis time and survival: Pursuing fashionable trends of dubious importance? José Vinhas
The prestigious Journal of the American Medical Association published a study in 2000 by Barbara Starfield which revealed the extremely poor performance of the United States health care system when compared to that of other industrialised nations.
Port J Nephrol Hypert 2016; 30(2): 102-103 Advance Access publication 17 May 2016 DOWNLOAD PDF
COMMENT Too Much Medicine: A commentary for nephrologists Richard J Glassock
The screening of populations of “apparently” health adults or children for the purpose of early detection of serious, possibly life-limiting diseases (such as cancer, heart or kidney disease) occurring in a pre-symptomatic form has become a very controversial issue in recent years.
Port J Nephrol Hypert 2016; 30(1): 000-000 Advance Access publication 15 March 2016 DOWNLOAD PDF
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