Online First

REVIEW ARTICLE Treatment options for type 2 diabetes mellitus in patientswith chronic kidney disease - old and new drugs Ana Ferreira, Filipa Bastos, Maria Carlos Cordeiro, Jorge Portugal
Chronic kidney disease is highly prevalent in patients with diabetes mellitus.
Port J Nephrol Hypert 2019; 33(2): 99-107 Advance Access publication 6 June 2019 DOWNLOAD PDF
TUBULAR QUIZ Hypokalemia in the setting of acute kidney injury and non-anion gap metabolic acidosis Nuno Moreira Fonseca, Patrícia Alves, David Navarro, João Sousa, Fernando Nolasco
We present a case of a 48-year-old female with past medical history of well-controlled hypertension who was diagnosed with Ewinglike sarcoma, with abdominal wall involvement and pulmonary metastatic lesions.
Port J Nephrol Hypert 2019; 33(2): 139-141 Advance Access publication 4 July 2019 DOWNLOAD PDF
COMMENT IgA immune complex deposits, what can lie behind them? Comments on a case of IgA dominant glomerulonephritis associated to staphylococcus infection. Fernanda Carvalho
In this journal Nicole Pestana et al. describe a case of “IgA dominant glomerulonephritis associated to staphylococcus infection”.
Port J Nephrol Hypert 2019; 33(2): 131 Advance Access publication 1 July 2019 DOWNLOAD PDF
REVIEW ARTICLE Vitamin D - New insights into an old molecule Cristina Jorge
New data on vitamin D has emerged in the last fifteen years and continues to expand practically every day.
Port J Nephrol Hypert 2019; 33(3): 145-152 Advance Access publication 23 September 2019 DOWNLOAD PDF
REVIEW ARTICLE Contrast agents in Nephrology - a literature review Sara Cardoso Fernandes, Ana Carina Ferreira
Contrast agents are widely used in ambulatory and hospitalized patients, as a complement to imaging studies, improving diagnostic accuracy.
Port J Nephrol Hypert 2019; 33(3): 153-157 Advance Access publication 23 September 2019 DOWNLOAD PDF
REVIEW ARTICLE Comprehensive geriatric assessment in nephrology Ana Farinha, Sofia Duque
In Portugal, in 2018, 64.5% of dialysis patients were elderly and nearly a quarter were older than 80 years.
Port J Nephrol Hypert 2019; 33(3): 159-166 Advance Access publication 27 September 2019 DOWNLOAD PDF
HOT TOPICS IN MEDICINE Carbapenem resistant Enterobacteriaceae - the basics for everymedical specialty Marisa Araújo, Carla Mimoso Santos, Daniela Lages
Enterobacteriaceae are ubiquitous gram‑negative bacilli, part of the intestinal flora.
Port J Nephrol Hypert 2019; 33(3): 167-172 Advance Access publication 1 October 2019 DOWNLOAD PDF
PERSPECTIVE Planning ESKD treatment: a plea for a stepwise person-centered approach including conservative care Helena Sá, Raymond Vanholder
A paradigm shift in the treatment of end-stage kidney disease (ESKD) is urgently needed.
Port J Nephrol Hypert 2019; 33(3): 177-182 Advance Access publication 8 October 2019 DOWNLOAD PDF
REVIEW ARTICLE Nephrotoxicity in patients receiving immune checkpoint inhibitors Teresa Chuva
Over the last years, immunotherapy has become part of the most important strategies to treat some types of cancer.
Port J Nephrol Hypert 2019; 33(4): 213-217 Advance Access publication ?? November 2019 DOWNLOAD PDF
COMMENT Alternative pathway complement activation in secondary thrombotic microangiopathies: is genetics the smoking gun? Joaquim Calado
Two different reports in the current PJHN highlight the mist that surrounds the role of the alternative pathway complement activation in secondary forms of thrombotic microangiopathies (TMA).
Port J Nephrol Hypert 2019; 33(4): 237 Advance Access publication ?? December 2019 DOWNLOAD PDF
REVIEW ARTICLE Magnesium supplementation to prevent recurrence of renal stones Ivo Laranjinha, Patricia Matias, Jorge Dickson
Stone formers have lower urinary magnesium than healthy people. Higher urinary magnesium levels are associated with lower incidence of kidney stones, and hypomagnesuria has been described as a lithogenic risk factor.
Port J Nephrol Hypert 2019; 33(4): 231-236 Advance Access publication 30 December 2019 DOWNLOAD PDF
CASE REPORT Nephrotic syndrome in a patient with metastatic melanoma: beyond the obvious Ana Messias, Joaquim Calado, Helena Viana, Fernando Nolasco
Nephrotic syndrome in a patient with metastatic melanoma can occur in the context of a paraneoplastic glomerulopathy or as a complication of treatment.
Port J Nephrol Hypert 2019; 33(4): 253-256 Advance Access publication 3 January 2020 DOWNLOAD PDF
PERSPECTIVE Make Urine Great Again Nuno Moreira Fonseca, David Navarro, Giuseppe Garigali, Giovanni Battista Fogazzi
Microscopic examination of urinary sediment (U‑sed) is an affordable and reliable diagnostic tool that constitutes a cornerstone of renal care.
Port J Nephrol Hypert 2019; 33(4): 227-230 Advance Access publication ?? December 2019 DOWNLOAD PDF
LETTER TO THE EDITOR Acute Kidney Injury in patients referred for ECMO therapy Anna Lima, Sílvia Coelho, Paulo Freitas
Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for critically ill patients with severe respiratory and/or circulatory failure, and its use has grown considerably in recent years.
Port J Nephrol Hypert 2020; 34(1): 31 Advance Access publication 25 March 2020 DOWNLOAD PDF
PERSPECTIVE A Nephro-Obstetric outpatient clinic model Estela Nogueira, Rita Calça, Iolanda Godinho, Luisa Pinto
Chronic kidney disease (CKD) is increasing worldwide and studies estimate that around 6% of women of childbearing age suffer from kidney disease.
Port J Nephrol Hypert 2020; 34(1): 3-10 Advance Access publication 23 March 2020 DOWNLOAD PDF
REVIEW ARTICLE Hyperuricemia in Chronic Kidney Disease: a role yet to be explained Rui Barata, Filipa Cardoso, Tiago Assis Pereira
The role of uric acid as an independent risk factor for chronic kidney disease development and progression is still a matter of discussion.
Port J Nephrol Hypert 2020; 34(1): 11-16 Advance Access publication 23 March 2020 DOWNLOAD PDF
REVIEW ARTICLE Doppler Ultrasound in Vascular Access care: the pearls and pitfalls of flow volume measurement Hugo Diniz, Luís Coentrão
Vascular access (VA) care is a critical part of the management of end‑stage renal disease.
Port J Nephrol Hypert 2020; 34(1): 25-30 Advance Access publication 25 March 2020 DOWNLOAD PDF
CASE REPORT Can cryoglobulinemia trigger ANCA vasculitis? Ivo Cunha, M. Teresa Santos, P. Ricardo Pereira
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a rare and heterogeneous group of autoimmune diseases.
Port J Nephrol Hypert 2020; 34(1): 21-24 Advance Access publication 25 March 2020 DOWNLOAD PDF
ORIGINAL ARTICLE Predictors of peritonitis in peritoneal dialysis: experience during 3 decades David Fiel, Joana Santos, Rita Vicente, Iolanda Santos, Beatriz Malvar, Rui Silva, Manuel Amoedo, Carlos Pires
Introduction: Peritonitis is a common complication in peritoneal dialysis patients and a major cause for dropout.
Port J Nephrol Hypert 2020; 34(1): 33-39 Advance Access publication 1 April 2020 DOWNLOAD PDF
CASE REPORT Primary hyperoxaluria type 1 - two case reports Inês Ganhão, Catarina Borges, Marta Amorim, Marisa Braga da Cruz, Susana Nobre, Telma Francisco, Dinorah Cardoso, Margarida Abranches
Background: Primary hyperoxaluria type 1 is a rare autosomal recessive inherited disease, caused by mutations in AGXT gene, with an estimated incidence of 1:100.000 live births per year in Europe.
Port J Nephrol Hypert 2020; 34(1): 55-57 Advance Access publication 1 April 2020 DOWNLOAD PDF
CASE REPORT Sarcoidosis: a case with pulmonary, cutaneous and renal injury Catarina Isabel Ribeiro, Susana Pereira, Ana Ventura, Clara Almeida, Clara Santos, João Carlos Fernandes
Sarcoidosis is a rare multisystem disease that is characterized by the formation of inflammatory granulomatous processes.
Port J Nephrol Hypert 2020; 34(1): 51-53 Advance Access publication 1 April 2020 DOWNLOAD PDF
REVIEW ARTICLE Treatment of lupus nephritis - past, present and (near) future David Navarro
The management of lupus nephritis is challenging for most nephrologists. Many trials have brought only a certain degree of evidence to the diagnosis and treatment of this disease, and many questions remain unanswered.
Port J Nephrol Hypert 2020; 34(1): 41-49 Advance Access publication 6 April 2020 DOWNLOAD PDF
CASE REPORT A physiological approach to recurrent nephrolithiasis and its genetic determinants Nuno Moreira Fonseca, Marine Livrozet, Rosa Varga-Poussou, Emmanuel Letavernier, Vincent Frochot, Michel Daudon, Jean-Philippe Haymann
We report a case of a 63-year-old patient with recurrent nephrolithiasis for over 40 years and a significant family history of nephrolithiasis.
Port J Nephrol Hypert 2020; 34(1): 17-19 Advance Access publication 6 April 2020 DOWNLOAD PDF
ACKNOWLEDGEMENT OF OUR REVIEWERS Thank you to our peer reviewers in 2019 --
Good and timely peer review is absolutely essential for the success of a journal. Therefore, we are most grateful for the support of those colleagues who have freely given their time and effort to review articles for the Portuguese Journal of Nephrology and Hypertension.
Port J Nephrol Hypert 2020; 34(1): 77 Advance Access publication 8 April 2020 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ Anemia, thrombocytopenia and acute kidney injury - a diagnostic challenge Sara Cardoso Fernandes, Ana Carina Ferreira, Mário Góis, Helena Viana, Fernando Nolasco
The authors present the case of a 72-year-old female with previous medical history of hypertension, ischemic cardiomyopathy and cerebrovascular disease with an ill-defined episode that resulted in brachial palsy.
Port J Nephrol Hypert 2020; 34(1): 73-75 Advance Access publication 9 April 2020 DOWNLOAD PDF
ORIGINAL ARTICLE Therapeutic plasma exchange in patients in a portuguese ICU Rita Calça, Ana Gaspar, Afonso Santos, Adelina Aufico, Paulo Freitas, Sílvia Coelho
Purpose: The aim of this study is to characterize a Portuguese Intensive Care Unit experience in therapeutic plasma exchange in critically ill patients.
Port J Nephrol Hypert 2020; 34(1): 67-71 Advance Access publication 10 April 2020 DOWNLOAD PDF
ORIGINAL ARTICLE ABO-incompatible living donor kidney transplantation in Portugal Catarina Isabel Ribeiro, Natália Silva, Jorge Malheiro, Manuela Almeida, Sofia Pedroso, Maria La Salete Martins, Leonídio Dias, António Castro Henriques, António Cabrita
Introduction: ABO incompatibility was considered a barrier to kidney transplant.
Port J Nephrol Hypert 2020; 34(1): 63-66 Advance Access publication 8 April 2020 DOWNLOAD PDF
PERSPECTIVE New Nephrology Departments: Challenges of the Future. Think big but start small Carlos Botelho
Portugal has the highest incident of chronic kidney disease (CKD) in Europe and the incidence and prevalence of advanced CKD requiring renal replacement therapy are higher than in other occidental European countries.
Port J Nephrol Hypert 2020; 34(1): 59-61 Advance Access publication 8 April 2020 DOWNLOAD PDF
LETTER TO THE EDITOR Comment on Doppler Ultrasound in Vascular Access care: The pearls and pitfalls of flow volume measurements Cora de Bont, Jan Malik, Kirk Beach
We have read the recent review of Diniz and Coentrão1 entitled “Doppler Ultrasound in Vascular Access care: the pearls and pitfalls of flow volume measurements’’ with a great interest.
Port J Nephrol Hypert 2020; 34(2): 73-74 Advance Access publication 25 March 2020 DOWNLOAD PDF
CASE REPORT Cancer screening in membranous nephropathy: How deep should we go? - A case report and literature review Luís Mendonça, Roberto Silva, Ana Teresa Nunes
Membranous nephropathy is the most common cause of nephrotic syndrome in white adults.
Port J Nephrol Hypert 2020; 34(2): 81-83 Advance Access publication 1 June 2020 DOWNLOAD PDF
REVIEW ARTICLE Anti-phospholipase A2 receptor antibodies: Current applications in primary membranous nephropathy Miguel Relvas, Rodrigo Batata, Ana Teresa Nunes, Luís Coentrão
Background: Membranous nephropathy (MN) is among the most common causes of nephrotic syndrome in nondiabetic adults.
Port J Nephrol Hypert 2020; 34(2): 85-92 Advance Access publication 1 June 2020 DOWNLOAD PDF
PERSPECTIVE The failing renal graft: A new chapter for CKD patients Rita Leal
Returning to dialysis after kidney transplant loss is one of the most difficult transitions for chronic kidney disease patients and their assistant nephrologists.
Port J Nephrol Hypert 2020; 34(1): 93-95 Advance Access publication 1 June 2020 DOWNLOAD PDF
CASE REPORT Urgent-Start Peritoneal Dialysis - a viable option? A case report and literature review Joana Tavares, Filipa Silva, Anna Lima, Maria João Carvalho, António Cabrita, Anabela Rodrigues
Background: Many patients with end‑stage renal disease start renal replacement therapy in an unplanned manner.
Port J Nephrol Hypert 2020; 34(2): 75-80 Advance Access publication 1 June 2020 DOWNLOAD PDF
TUBULAR QUIZ A case of extreme alkalosis - the perfect combination of perpetuators Patrícia Valério, Hugo Ferreira, Teresa Chuva, Ana Paiva, Inês Neves, Filomena Faria, José Maximino
A 70‑year‑old Caucasian male, with an ECOG1 performance status of 1, was admitted in August 2019 for an elective surgery due to a stage II bladder urothelial carcinoma (pT2N0M0).
Port J Nephrol Hypert 2020; 34(2): 97-100 Advance Access publication 8 July 2020 DOWNLOAD PDF
ORIGINAL ARTICLE Anemia and iron deficiency diagnosis, management and treatment in chronic kidney disease ? Consensus and agreement through a Delphi Panel Aníbal Ferreira on behalf of the group: Ana Farinha, Ana Macedo, António Robalo Nunes, José Lopes, Patrícia Branco, Pedro Ponce, Ricardo Neto
Port J Nephrol Hypert 2020; 34(2): 101-105 Advance Access publication 1 June 2020 DOWNLOAD PDF
CASE REPORT Neutropenic enterocolitis (typhlitis) in a kidney transplant patient: A case report Rita Valério Alves, Luís Falcão, Elsa Soares, Milena Mendes, Patrícia Cotovio, Fernando Caeiro, Inês Aires, Cecília Silva, Francisco Remédio, Aníbal Ferreira, Fernando Nolasco
Typhlitis is a clinical entity rare in adults, reported in immunosuppressed patients.
Port J Nephrol Hypert 2020; 34(2): 115-117 Advance Access publication 1 June 2020 DOWNLOAD PDF
CASE REPORT Atheroembolic renal disease and rivaroxaban: A new association Catarina Isabel Ribeiro, Clara Almeida, Ana Ventura, Clara Santos, João Carlos Fernandes
Atheroembolic renal disease is a multisystem clinical entity of unknown incidence.
Port J Nephrol Hypert 2020; 34(2): 111-113 Advance Access publication 1 June 2020 DOWNLOAD PDF
PERSPECTIVE Access to kidney transplantation: a bioethical perspective Bruno A Lima, Helena Alves
When possible, kidney transplantation is the best renal replacement treatment for end stage renal disease patients.
Port J Nephrol Hypert 2020; 34(1): 107-109 Advance Access publication 1 June 2020 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ Several faces of multiple myeloma Maria do Mar Menezes, Elsa Soares, Mário Góis, Helena Viana, Fernando Nolasco
We present a case of a 71-year-old woman with past medical history of hypertension and multiple myeloma (MM) IgG kappa for three years.
Port J Nephrol Hypert 2020; 34(2): 125-127 Advance Access publication 9 June 2020 DOWNLOAD PDF
REVIEW ARTICLE Kidney-induced osteoporosis: a new entity with a novel therapeutic approach Ana Beatriz de Oliveira Pereira,João Miguel Machado Dória Frazão
Over the past century, important scientific advances have been made regarding the complex pathophysiology of bone disease in renal patients.
Port J Nephrol Hypert 2020; 34(2): 129-137 Advance Access publication 9 June 2020 DOWNLOAD PDF
REVIEW ARTICLE Palliative interventions in outpatient dialysis network Ana Branco, Ana Farinha, Ana Mateus, Cristina Outerelo, Pedro Ponce
Chronic kidney disease (CKD) is a burdensome disease that has been successfully managed with dialysis.
Port J Nephrol Hypert 2020; 34(2): 119-124 Advance Access publication 9 June 2020 DOWNLOAD PDF
REVIEW ARTICLE Membranous nephropathy: an update Hernando Trujillo, Manuel Praga
Great advances have been made in the pathophysiologic and therapeutic areas of membranous nephropathy in the last years.
Port J Nephrol Hypert 2019; 33(1): 10-18 Advance Access publication 18 February 2019 DOWNLOAD PDF

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