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ORIGINAL ARTICLE In-hospital and one-year mortality among patients with acute kidney injury and hematological malignancies Inês Coelho, Teresa Chuva, Hugo Ferreira, Ana Paiva, José M. Costa
Hematological malignancies (HM) confer a high risk of acute kidney injury (AKI), which is associated with elevated morbi-mortality.
Port J Nephrol Hypert 2021; 35(1): 11-17 Advance Access publication 14 April 2021 DOWNLOAD PDF
CASE REPORT Acute hyperammonemic encephalopathy - an indication for an extracorporeal depuration technique A case report and literature review Filipa Silva, Joana Tavares, Ana Castro, Arlindo Guimas, Cristina Freitas, João Pedro Pimentel, António Cabrita
Introduction: Ammonia is a resultant molecule from the protein metabolism that can be neurotoxic when present in high concentrations, causing brain edema and encephalopathy.
Port J Nephrol Hypert 2021; 35(1): 43-46 Advance Access publication 14 April 2021 DOWNLOAD PDF
ORIGINAL ARTICLE Prognostic value of lymphocyte cell ratios in peritoneal dialysis Roberto C. Marques, Eduarda C. Carias, Ana T. Domingos, Anabela M. Guedes, Idalécio Bernardo, Pedro L. Neves
Background: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been introduced as useful inflammatory markers to predict the outcome of a wide spectrum of diseases, such as malignancies and cardiovascular pathologies.
Port J Nephrol Hypert 2021; 35(1): 18-21 Advance Access publication 14 April 2021 DOWNLOAD PDF
CASE REPORT A case of lupus podocytopathy and a review of the literature José Silvano, Augusta Praça, Inês Castro Ferreira, Ana Teresa Nunes, Pedro Rodrigues-Pereira, Roberto Pestana Silva, Susana Sampaio, Manuel Pestana
Nephrotic syndrome in systemic lupus erythematosus patients with histological evidence of minimal change disease, mesangial proliferation or focal and segmental glomerulosclerosis on light microscopy, represents a distinct clinical entity – lupus podocytopathy
Port J Nephrol Hypert 2021; 35(1): 39-42 Advance Access publication 14 Abril 2021 DOWNLOAD PDF
REVIEW ARTICLE High serum bicarbonate and adverse outcomes in hemodialysis patients Gonçalo Ávila, Ivo Laranjinha, Patrícia Matias
Metabolic acidosis is a usual complication of progressive chronic kidney disease and is associated with morbidity and mortality. The correction of metabolic acidosis is a main goal of dialysis.
Port J Nephrol Hypert 2021; 35(1): 35-38 Advance Access publication 14 April 2021 DOWNLOAD PDF
CASE REPORT Systemic lupus erythematosus and ANCA-associated vasculitis overlap syndrome: A case report and literature review of poliautoimmunity Ana Gaspar, Anna Lima, Afonso Santos, Catarina Brás, Rita Theias Manso, Karina Soto
Systemic lupus erythematosus and ANCA-associated vasculitis overlap syndrome is rare and complex.
Port J Nephrol Hypert 2021; 35(1): 47-50 Advance Access publication 14 April 2021 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ Kidney graft dysfunction in a patient with SARS-CoV-2 pneumonia - Not everything is COVID 19 Cátia Figueiredo, Patrícia Valério, Helena Sousa, Mário Góis, Fernando Nolasco
We present a case of a 46-year-old African male with chronic kidney disease secondary to hypertensive nephropathy, in hemodialysis for five years.
Port J Nephrol Hypert 2021; 35(1): 59-62 Advance Access publication 15 April 2021 DOWNLOAD PDF
ORIGINAL ARTICLE The role of incremental peritoneal dialysis among patients on peritoneal dialysis. A longitudinal analysis over 20 years Joana Eugénio Santos, Rui Silva, Rita Vicente, Iolanda Santos, Miguel Coimbra, David Fiel, Manuel Amoedo, Carlos Pires
Background: There is an ongoing increasing focus on person‑centered individualized dialysis prescription.
Port J Nephrol Hypert 2021; 35(1): 22-28 Advance Access publication 14 April 2021 DOWNLOAD PDF
ORIGINAL ARTICLE Fabry disease in patients under dialysis: A screening study and identification of a novel mutation Francisca Gomes da Silva, Nicole Pestana, José Durães, Nuno Guimarães Rosa, Gil Silva
Fabry disease (FD) is a rare systemic disease, with a large spectrum of disease severity.
Port J Nephrol Hypert 2021; 35(1): 29-34 Advance Access publication 14 April 2021 DOWNLOAD PDF
PERSPECTIVE Portuguese Nephrology: We can be greener Diogo Francisco, Ivo Laranjinha
Healthcare facilities are among the greatest contributors to resource consumption and waste generation.
Port J Nephrol Hypert 2021; 35(1): 6-10 Advance Access publication 14 April 2021 DOWNLOAD PDF
CASE REPORT Lupus nephritis with an unusual histopathological pattern Marcelo Aveiro, Nicole Pestana, Francisca Silva, Pedro Vieira, Nuno Rosa, Gil Silva
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple organs.
Port J Nephrol Hypert 2021; 35(1): 51-54 Advance Access publication 15 April 2021 DOWNLOAD PDF
CASE REPORT The misleading laboratory results: Renal impairment associated with high anti myeloperoxidase titer (anti-MPO) does not always mean ANCA vasculitis Mariana Sousa, Cristina Santos, Rita Gouveia, Fernando Pereira, Rita Manso, Jorge Silva
Introduction: Antineutrophil cytoplasmic autoantibodies (ANCAs) are crucial in the pathogenesis of ANCA-associated glomerulonephritis.
Port J Nephrol Hypert 2021; 35(1): 55-58 Advance Access publication 15 April 2021 DOWNLOAD PDF
PERSPECTIVE Nephrolithiasis is not a stone in the nephrologist's shoe Ivo Laranjinha, Jorge Dickson
The prevalence of kidney stones (KS) is increasing and occurring sooner in life.
Port J Nephrol Hypert 2021; 35(1): 3-5 Advance Access publication 14 April 2021 DOWNLOAD PDF
LETTER TO THE EDITOR Incidence in dialysis and chronic kidney disease prevalencein the Portuguese population M. Martins Prata
Portugal has the highest incidence of dialysis in Europe and one of the highest in the world. 
Port J Nephrol Hypert 2021; 35(1): 63 Advance Access publication xx April 2021 DOWNLOAD PDF
REVIEW ARTICLE Treatment of lupus nephritis - past, present and (near) future David Navarro
The management of lupus nephritis is challenging for most nephrologists. Many trials have brought only a certain degree of evidence to the diagnosis and treatment of this disease, and many questions remain unanswered.
Port J Nephrol Hypert 2020; 34(1): 41-49 Advance Access publication 6 April 2020 DOWNLOAD PDF
CASE REPORT Cancer screening in membranous nephropathy: How deep should we go? - A case report and literature review Luís Mendonça, Roberto Silva, Ana Teresa Nunes
Membranous nephropathy is the most common cause of nephrotic syndrome in white adults.
Port J Nephrol Hypert 2020; 34(2): 81-83 Advance Access publication 1 June 2020 DOWNLOAD PDF
REVIEW ARTICLE Anti-phospholipase A2 receptor antibodies: Current applications in primary membranous nephropathy Miguel Relvas, Rodrigo Batata, Ana Teresa Nunes, Luís Coentrão
Background: Membranous nephropathy (MN) is among the most common causes of nephrotic syndrome in nondiabetic adults.
Port J Nephrol Hypert 2020; 34(2): 85-92 Advance Access publication 1 June 2020 DOWNLOAD PDF
PERSPECTIVE The failing renal graft: A new chapter for CKD patients Rita Leal
Returning to dialysis after kidney transplant loss is one of the most difficult transitions for chronic kidney disease patients and their assistant nephrologists.
Port J Nephrol Hypert 2020; 34(1): 93-95 Advance Access publication 1 June 2020 DOWNLOAD PDF
CASE REPORT Urgent-Start Peritoneal Dialysis - a viable option? A case report and literature review Joana Tavares, Filipa Silva, Anna Lima, Maria João Carvalho, António Cabrita, Anabela Rodrigues
Background: Many patients with end‑stage renal disease start renal replacement therapy in an unplanned manner.
Port J Nephrol Hypert 2020; 34(2): 75-80 Advance Access publication 1 June 2020 DOWNLOAD PDF
TUBULAR QUIZ A case of extreme alkalosis - the perfect combination of perpetuators Patrícia Valério, Hugo Ferreira, Teresa Chuva, Ana Paiva, Inês Neves, Filomena Faria, José Maximino
A 70‑year‑old Caucasian male, with an ECOG1 performance status of 1, was admitted in August 2019 for an elective surgery due to a stage II bladder urothelial carcinoma (pT2N0M0).
Port J Nephrol Hypert 2020; 34(2): 97-100 Advance Access publication 8 July 2020 DOWNLOAD PDF
ORIGINAL ARTICLE Anemia and iron deficiency diagnosis, management and treatment in chronic kidney disease ? Consensus and agreement through a Delphi Panel Aníbal Ferreira on behalf of the group: Ana Farinha, Ana Macedo, António Robalo Nunes, José Lopes, Patrícia Branco, Pedro Ponce, Ricardo Neto
Port J Nephrol Hypert 2020; 34(2): 101-105 Advance Access publication 1 June 2020 DOWNLOAD PDF
CASE REPORT Neutropenic enterocolitis (typhlitis) in a kidney transplant patient:A case report Rita Valério Alves, Luís Falcão, Elsa Soares, Milena Mendes, Patrícia Cotovio, Fernando Caeiro, Inês Aires, Cecília Silva, Francisco Remédio, Aníbal Ferreira, Fernando Nolasco
Typhlitis is a clinical entity rare in adults, reported in immunosuppressed patients.
Port J Nephrol Hypert 2020; 34(2): 115-117 Advance Access publication 1 June 2020 DOWNLOAD PDF
CASE REPORT Atheroembolic renal disease and rivaroxaban: A new association Catarina Isabel Ribeiro, Clara Almeida, Ana Ventura, Clara Santos, João Carlos Fernandes
Atheroembolic renal disease is a multisystem clinical entity of unknown incidence.
Port J Nephrol Hypert 2020; 34(2): 111-113 Advance Access publication 1 June 2020 DOWNLOAD PDF
PERSPECTIVE Access to kidney transplantation: a bioethical perspective Bruno A Lima, Helena Alves
When possible, kidney transplantation is the best renal replacement treatment for end stage renal disease patients.
Port J Nephrol Hypert 2020; 34(1): 107-109 Advance Access publication 1 June 2020 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ Several faces of multiple myeloma Maria do Mar Menezes, Elsa Soares, Mário Góis, Helena Viana, Fernando Nolasco
We present a case of a 71-year-old woman with past medical history of hypertension and multiple myeloma (MM) IgG kappa for three years.
Port J Nephrol Hypert 2020; 34(2): 125-127 Advance Access publication 9 June 2020 DOWNLOAD PDF
REVIEW ARTICLE Kidney-induced osteoporosis: a new entity with a novel therapeutic approach Ana Beatriz de Oliveira Pereira,João Miguel Machado Dória Frazão
Over the past century, important scientific advances have been made regarding the complex pathophysiology of bone disease in renal patients.
Port J Nephrol Hypert 2020; 34(2): 129-137 Advance Access publication 9 June 2020 DOWNLOAD PDF
REVIEW ARTICLE Palliative interventions in outpatient dialysis network Ana Branco, Ana Farinha, Ana Mateus, Cristina Outerelo, Pedro Ponce
Chronic kidney disease (CKD) is a burdensome disease that has been successfully managed with dialysis.
Port J Nephrol Hypert 2020; 34(2): 119-124 Advance Access publication 9 June 2020 DOWNLOAD PDF
CASE REPORT Rescuing the nephrologist's main central vein - placementof a right jugular vein catheter in a patient with thoraciccentral venous occlusion by use of the Surfacer® device Nuno Afonso, Luís Rodrigues, Emanuel Ferreira, Helena Pinto, Rui Nogueira, Gabriel Anacleto, Manuel Fonseca, Rui Alves
Central venous stenosis can be the main obstacle to the creation of a vascular access.
Port J Nephrol Hypert 2020; 34(3): 140-144 Advance Access publication 23 September 2020 DOWNLOAD PDF
ORIGINAL SARS-CoV-2 infection in hemodialysis patients: Preliminary data from a Portuguese hospital center Joana Tavares, Bruno Fraga Dias, João Pedro Oliveira, Inês Sala, Filipa Silva, Ana Castro, Cristina Freitas, Tomás Fonseca, João Pedro Pimentel, António Cabrita, Rui Sarmento e Castro
Background: In December 2019, a new form of coronavirus was identified (COVID‑19) and quickly became a worldwide pandemic.
Port J Nephrol Hypert 2020; 34(3): 135-139 Advance Access publication 23 September 2020 DOWNLOAD PDF
TUBULAR QUIZ Failure to thrive in a pediatric patient Filipa Valadares, Rute Baeta Baptista, Telma Francisco, Margarida Abranches
A three-month-old boy was referred to our hospital for the study and management of metabolic acidosis and failure to thrive.
Port J Nephrol Hypert 2020; 34(3): 156-159 Advance Access publication 24 September 2020 DOWNLOAD PDF
LETTER TO THE EDITOR Impact of COVID 19, an Indian nephrologist's perspective Abhilash Chandra, Namrata Rao, Divya Srivastava
India saw its first case of corona virus disease (COVID) 2019 on 30th January 2020. With the virus expanding across continents, it was a certainty that India would also be affected.
Port J Nephrol Hypert 2020; 34(3): 155 Advance Access publication 23 September 2020 DOWNLOAD PDF
REVIEW ARTICLE Antibody mediated rejection. Evidence based medicine.What is the current evidence? Maria do Mar Menezes, Inês Aires, Fernando Nolasco
Antibody mediated rejection (ABMR) is a major cause of kidney graft loss.
Port J Nephrol Hypert 2020; 34(3): 145-151 Advance Access publication 23 September 2020 DOWNLOAD PDF
CASE REPORT Rituximab-induced hypersensitivity pneumonitis in a kidney transplant patient Natália Silva, Catarina Isabel Ribeiro, Manuela Almeida, Jorge Malheiro, Sofia Pedroso, Maria La Salete Mart
Rituximab (RTX) is a chimeric anti‑CD20 monoclonal antibody that has been associated with delayed pulmonary 
Port J Nephrol Hypert 2020; 34(3): 152-154 Advance Access publication 23 September 2020 DOWNLOAD PDF
CASE REPORT Daratumumab: A new future for AL-Amyloidosis and Multiple Myeloma. Clara Pardinhas, Luís Francisco, Luís Escada, Vítor Sousa, Rui Alves
Concomitant development of symptomatic amyloid light-chain (AL) amyloidosis and multiple myeloma (MM) is rare and has a poor survival rate.
Port J Nephrol Hypert 2020; 34(3): 160-163 Advance Access publication 2 October 2020 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ The importance of graft kidney biopsy: A case of proteinuria one week after transplantation Mariana Sousa, Luís Falcão, Rita Calça, Mário Gois, Helena Viana, Fernando Nolasco
We present a case of a 39-year-old African male with chronic kidney disease secondary to primary membranous nephropathy with positive anti-phospholipase A2 receptor autoantibodies (anti-PLA2R), in hemodialysis for one year.
Port J Nephrol Hypert 2020; 34(2): 181-183 Advance Access publication 7 October 2020 DOWNLOAD PDF
ORIGINAL ARTICLE Kidney disease in tuberous sclerosis complex: A single-center experience Joana Lorenzo, Catarina Isabel Ribeiro, Rita Russo Belo, Liane Costa, Ana Teixeira, Liliana Rocha, Teresa Costa, Paula Pires Matos, Maria do Sameiro Faria, Conceição Mota
Tuberous sclerosis complex is an autosomal dominant neurocutaneous disorder which is characterized by multisystem involvement, including the kidney.
Port J Nephrol Hypert 2020; 34(3): 173-175 Advance Access publication 7 October 2020 DOWNLOAD PDF
REVIEW ARTICLE New treatments in membranous glomerulopathy - from the pitfalls of rituximab to a new era of biological treatments Filipa Ferreira, Ana Teresa Nunes
Primary membranous nephropathy (PMN) is the main cause of nephrotic syndrome in adults.
Port J Nephrol Hypert 2020; 34(3): 176-180 Advance Access publication 7 October 2020 DOWNLOAD PDF
ORIGINAL ARTICLE Validation of a model to predict six-month mortality in incident elderly dialysis patients Josefina Santos, Pedro Oliveira, Jorge Malheiro, Andreia Campos, Sofia Correia, António Cabrita, Luísa Lobato, Isabel Fonseca
To evaluate RRT benefits and risks and to inform patients and their families about ESRD treatment options, we have developed a prognostic score to predict 6-month mortality in elderly ESRD patients initiating dialysis.
Port J Nephrol Hypert 2020; 34(3): 167-173 Advance Access publication 8 October 2020 DOWNLOAD PDF
REVIEW ARTICLE COVID-19 and acute kidney injury - A new medical condition Natália Silva, Catarina Isabel Ribeiro
Novel Coronavirus disease (COVID-19) is a newly discovered contagious disease that has affected many countries around the world.
Port J Nephrol Hypert 2020; 34(4): 221-224 Advance Access publication 15 December 2020 DOWNLOAD PDF
REVIEW ARTICLE Acute kidney injury in SARS-COV-2 infection Oswaldo Jesus Rodrigues da Mottaa, Jaqueline Machado da Fonsecab, Isadora de Carvalho e Silvab, Flávio Marques Andreonc, Lorena Souza e Silvad, Andréia Patrícia Gomese, Paulo Sérgio Balbino Miguele
The current pandemic of COVID‑19 – Coronavirus Disease‑19, caused by the pathogen SARS‑Cov‑2, responsible for thousands of deaths in 2020, has mobilized the scientific community, who aim to understand the different aspects of the disease and propose new treatments and prevention modalities.
Port J Nephrol Hypert 2020; 34(3): 186-188 Advance Access publication 7 October 2020 DOWNLOAD PDF
CASE REPORT Simultaneous pancreas-kidney transplantation after liver transplantation: first Portuguese case report Elsa Soares, Rita Valério Alves, Patrícia Cotovio, Fernando Caeiro, Inês Aires, Miguel Bigotte, Cecília Silva, Ana Pena, Luís Bicho, Américo Martins, Francisco Remédio, Aníbal Ferreira, Fernando Nolas
Simultaneous kidney pancreas transplantation, if feasible, is the treatment of choice for the management of end-stage renal disease in patients with type 1 diabetes.
Port J Nephrol Hypert 2020; 34(3): 164-166 Advance Access publication 9 October 2020 DOWNLOAD PDF
REVIEW ARTICLE End stage kidney disease in the elderly: Hope for the best Patrícia Valério, Ana Farinha
With an increased number of aged chronic kidney disease (CKD) patients, along with medical and technological advances, the options to approach end‑stage kidney disease (ESKD) have multiplied.
Port J Nephrol Hypert 2020; 34(4): 225-232 Advance Access publication 21 December 2020 DOWNLOAD PDF
ORIGINAL ARTICLE Online hemofiltration in incremental dialysis prescription Sofia Oliveira Correia, Filipa Santos Silva, Joana Tavares, António Cabrita, José Queirós
Incremental dialysis is increasingly recognized as a safe and beneficial method of initiating dialysis.
Port J Nephrol Hypert 2020; 34(4): 204-210 Advance Access publication 21 December 2020 DOWNLOAD PDF
ORIGINAL ARTICLE A cost-effective analysis of drug-eluting balloon in highly recurrent stenosis on dialysis vascular access Telmo Carvalho, Dulce Carvalho, Patrícia Marujo, Maria David, João Cruz, Pedro Maia, Pedro Ponce
Background: The efficacy and cost-effectiveness of drug-eluting balloon (DEB) in vascular access for dialysis remain unclear.
Port J Nephrol Hypert 2020; 34(4): 211-216 Advance Access publication 6 January 2021 DOWNLOAD PDF
ORIGINAL ARTICLE COVID-19 patients on hemodialysis: a hospital experience B. Oliveira Ribeiroa, M. Vicente Toméb, S. Homem de Melo Marquesa, R. Vieira Carvalhoa, A. Nunes Ramalheiroa
Introduction: SARS‑CoV2 represents a challenge for hemodialysis (HD). By August 24 2020, the disease had affected 55720 people in Portugal.
Port J Nephrol Hypert 2020; 34(4): 217-220 Advance Access publication 8 January 2021 DOWNLOAD PDF
REVIEW ARTICLE Extracorporeal light chains removal - What role does this play in 2020? Inês Coelho, Hugo Ferreira, Teresa Chuva, Ana Paiva, José Maximino
Multiple Myeloma (MM) is characterized by a neoplastic proliferation of plasma cell clones producing monoclonal immunoglobulin.
Port J Nephrol Hypert 2020; 34(4): 233-238 Advance Access publication 6 January 2021 DOWNLOAD PDF
CASE REPORT Clinical perspectives to improve pregnancy outcome in women undergoing chronic hemodialysis Luiz Paulo José Marques, Regina Rocco, Paulo Roberto Silva Marinho, Eugênio Pacelle Queiroz Madeira, Lygia Maria Soares Fernandes Vieira
Severe Chronic Kidney Disease is considered a powerful method of contraception per se, and pregnancy among women undergoing chronic hemodialysis is a rare event.
Port J Nephrol Hypert 2020; 34(4): 244-247 Advance Access publication 6 January 2021 DOWNLOAD PDF
CASE REPORT From light chain deposition to multiple myeloma - Case report and literature review Ana Domingos, Joana Vidinha, Anabela Guedes, Ana Macedo, Mário Góis, Pedro Leão Neves
Monoclonal gammopathies consist of a broad spectrum of diseases, ranging from asymptomatic monoclonal gammopathy of undetermined significance to multiple myeloma (MM).
Port J Nephrol Hypert 2020; 34(4): 239-243 Advance Access publication 21 December 2020 DOWNLOAD PDF
PERSPECTIVE A quest for improving the quality and utility of the individual registry of patients starting renal replacement therapy in Portugal Edgar A F de Almeida, Anabela Rodrigues
Portugal has one of the highest rates of prevalence and incidence of dialysis in Europe.
Port J Nephrol Hypert 2020; 34(4): 193-194 Advance Access publication 21 December 2020 DOWNLOAD PDF
PERSPECTIVE The rediscovery of nephropathology with artificial intelligence Luís Rodrigues, Pinaki Sarder, Kuang-Yu Jen, Brandon Ginley, Jorge Pratas, Vitor Sousa, Arnaldo Figueiredo, Rui Alves
A kidney biopsy is a beloved tool for most nephrologists. It is as old as nephrology itself, and for the last fifty years, it has helped us to understand the pathophysiology of kidney disease and offer the best care to our patients.
Port J Nephrol Hypert 2020; 34(4): 195-197 Advance Access publication 6 January 2021 DOWNLOAD PDF
PERSPECTIVE Ultrasound in vascular access management ? How to start and enhance a comprehensive program Tiago Assis Pereira
Diagnostic medicine has evolved from a solely physical examination to a setting where a diversity of complementary diagnostic methods is applied.
Port J Nephrol Hypert 2020; 34(4): 198-203 Advance Access publication 6 January 2021 DOWNLOAD PDF
LETTER TO THE EDITOR Acquired thrombotic thrombocytopenic purpura: Caplacizumab as a novel therapeutic option Miguel Relvas, Maria Lume, Fernando Friões, Luís Coentrão
Thrombotic thrombocytopenic purpura (TTP) is a medical emergency among primary thrombotic microangiopathies that relates to decreased activity of ADAMTS13
Port J Nephrol Hypert 2020; 34(4): 254-255 Advance Access publication 21 December 2020 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ Hepatitis B virus infection and the kidney: a wide range of manifestations Rui Barata, Patrícia Alves, Tiago Assis Pereira, Mário Góis, Helena Viana, Fernando Nolasco
We present a case of a 46-year-old African male referred for chronic kidney disease.
Port J Nephrol Hypert 2020; 34(4): 248-250 Advance Access publication 6 January 2021 DOWNLOAD PDF
TUBULAR QUIZ A case of polyuria Joaquim Calado
We present the case of a 39‑year‑old woman referred to the nephrology outpatient unit with polyuria (daily urinary output of 12 L).
Port J Nephrol Hypert 2020; 34(4): 251-253 Advance Access publication 6 January 2021 DOWNLOAD PDF

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